2-Minute Neuroscience: Methadone

Methadone is commonly used to treat opioid use disorder even though its pharmacological action is very similar to that of other opioids like morphine. In this video, I discuss the qualities that make methadone an effective treatment for opioid addiction, along with how it acts to reduce the risks associated with opioid abuse. TRANSCRIPT: Welcome to 2-minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss methadone. Methadone is best known for its use in the treatment of opioid addiction, although it can also be used for treating chronic pain. It’s usually administered by mouth in the form of a liquid, pill, or sublingual tablet. Methadone’s primary mechanism of action is as an agonist at opioid receptors. In other words, it activates opioid receptors similar to the way other opioid drugs like morphine would. It also acts as an antagonist, or blocks, NMDA glutamate receptors, which is thought to contribute to its pain-relieving effects. Because it has a similar mechanism of action to other opioids, methadone causes enough stimulation of opioid receptors to reduce cravings for other opioid drugs and to prevent a patient from experiencing withdrawal symptoms. Unlike most other opioids, however, methadone typically only has to be administered once a day to achieve these effects. Additionally, methadone occupies opioid receptor binding sites, which diminishes any effect administration of another opioid might have, further discouraging someone from using other opioid drugs while taking methadone. Altogether, methadone’s pharmacological action lowers the likelihood a patient will abuse other opioid drugs. Since methadone has a similar mechanism of action to other opioids, patients also often become dependent on methadone, and some may need to take the drug for a prolonged period of time, or even for the rest of their life. Because the drug is administered by a medical professional, however, doses can be controlled, and the risk of fatal and nonfatal overdose for someone on methadone is much lower than for someone who continues abusing opioids. Additionally, methadone treatment is associated with a reduction in intravenous drug use, and thus a lower risk of contracting blood-borne diseases like HIV. References: Blanco C1, Volkow ND2. Management of opioid use disorder in the USA: present status and future directions. Lancet. 2019 Apr 27;393(10182):1760-1772. doi: 10.1016/S0140-6736(18)33078-2. Epub 2019 Mar 14. Salsitz E1, Wiegand T2. Pharmacotherapy of Opioid Addiction: "Putting a Real Face on a False Demon". J Med Toxicol. 2016 Mar;12(1):58-63. doi: 10.1007/s13181-015-0517-5.

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